[循环血清STN抗原作为上皮性卵巢癌的预后标志物]

[Circulating serum STN antigen as a prognostic marker in epithelial ovarian cancer].

作者信息

Kobayashi H, Terao T, Kawashima Y

机构信息

Dept. of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.

出版信息

Gan To Kagaku Ryoho. 1991 Aug;18(10):1651-5.

PMID:1678592

Abstract

Circulating serum sialyl Tn (STN) antigen levels were measured in 89 patients with epithelial ovarian cancer. Survival at 5 years for patients with STN-negative (serum STN levels less than 50 U/ml) versus STN-positive tumors (serum STN levels greater than or equal to 50 U/ml) was 76.9% versus 10.8%, respectively (p less than 0.05). The overall survival probability was worse in patients with STN-positive sera. Percent progression-free survival at 5 years for patients with STN-negative versus STN-positive tumors was 51.9% versus 5.4%, respectively (p less than 0.05). The overall progression-free survival was shorter in patients with STN-positive sera. Multivariate regression analysis revealed that positive STN antigen level in sera is an independent predictor of poor prognosis in epithelial ovarian cancer.

摘要

对89例上皮性卵巢癌患者测定了循环血清唾液酸Tn（STN）抗原水平。STN阴性（血清STN水平低于50 U/ml）与STN阳性肿瘤（血清STN水平大于或等于50 U/ml）患者的5年生存率分别为76.9%和10.8%（p<0.05）。STN阳性血清患者的总生存概率更差。STN阴性与STN阳性肿瘤患者的5年无进展生存率分别为51.9%和5.4%（p<0.05）。STN阳性血清患者的总体无进展生存期较短。多变量回归分析显示，血清中STN抗原水平阳性是上皮性卵巢癌预后不良的独立预测因素。