Tollesson P O, Cassuto J, Faxén A, Rimbäck G, Mattsson E, Rosén S
Department of Radiology, Central Hospital, Mölndal, Sweden.
Eur J Surg. 1991 May;157(5):355-8.
The effect of metoclopramide on postoperative colonic ileus was evaluated in a randomised, double-blind study in 20 patients after cholecystectomy. The start of propulsive colonic motility and colonic transit time after operation were measured by radio-opaque markers and serial abdominal radiographs. Metoclopramide 20 mg given intravenously three times a day until the fourth postoperative day (n = 10) did not significantly reduce the duration of postoperative colonic paralysis compared with control patients (n = 10), nor were there any differences between the groups when the time of first postoperative passage of gas and faeces were compared. In conclusion, the use of metoclopramide in the postoperative period did not result in a quicker return of propulsive motility in the right or left colon as judged by the radio-opaque markers and serial abdominal radiographs.
在一项针对20例胆囊切除术后患者的随机双盲研究中，评估了甲氧氯普胺对术后结肠麻痹的影响。通过不透X线标志物和系列腹部X线片测量术后推进性结肠运动的开始时间和结肠运输时间。与对照组患者（n = 10）相比，每天静脉注射3次20 mg甲氧氯普胺直至术后第4天（n = 10）并没有显著缩短术后结肠麻痹的持续时间，比较两组术后首次排气和排便时间时也没有差异。总之，根据不透X线标志物和系列腹部X线片判断，术后使用甲氧氯普胺并没有使右半结肠或左半结肠的推进性运动更快恢复。
