Ohno Hiroshi
Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology (RCAI), RIKEN, Yokohama.
J Biochem. 2006 Jun;139(6):941-2. doi: 10.1093/jb/mvj119.
Membrane traffic is a fundamental cellular function by which molecules are transported between organelles in the post-Golgi network. Accumulating evidence supports the notion that membrane traffic is not only indispensable for normal cellular function and maintenance of cellular viability by playing housekeeping roles, but also critical for various functions characteristic of multicellular organisms. This Minireview series will focus on the latter aspects of membrane traffic. The topics discussed are: the pathophysiological impact of clathrin-associated adaptor protein (AP) complexes, the significance of membrane traffic in Alzheimer's disease, regulated exocytosis of insulin, secretory lysosomes in immune response, exosomes in physiology and pathology, viral and mammalian ubiquitin ligases modulating immune response, membrane traffic of bacterial toxins, and containment of bacterial infection by autophagy.
膜运输是一种基本的细胞功能，通过该功能分子在后高尔基体网络中的细胞器之间进行转运。越来越多的证据支持这样一种观点，即膜运输不仅通过发挥管家作用对正常细胞功能和维持细胞活力不可或缺，而且对多细胞生物的各种功能特征也至关重要。本系列小型综述将聚焦于膜运输的后一个方面。讨论的主题包括：网格蛋白相关衔接蛋白（AP）复合物的病理生理影响、膜运输在阿尔茨海默病中的意义、胰岛素的调节性胞吐作用、免疫反应中的分泌性溶酶体、生理和病理中的外泌体、调节免疫反应的病毒和哺乳动物泛素连接酶、细菌毒素的膜运输以及自噬对细菌感染的控制。
