Voruganti V Saroja, Cai Guowen, Cole Shelley A, Freeland-Graves Jeanne H, Laston Sandra, Wenger Charlotte R, MacCluer Jean W, Dyke Bennett, Devereux Richard, Ebbesson Sven O E, Fabsitz Richard R, Howard Barbara V, Comuzzie Anthony G
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227-5301, USA.
Am J Hum Biol. 2006 Jul-Aug;18(4):525-31. doi: 10.1002/ajhb.20527.
Increasing incidence of cardiovascular disease in traditionally low-risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low-density lipoprotein (LDL) subfractions with obesity-related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influence were calculated using a maximum likelihood variance component method implemented in SOLAR. Mean values of weight, body mass index (BMI), and waist were 73.4 +/- 0.5 kg, 27.6 +/- 0.2 kg/m2, and 88.0 +/- 0.4 cm, respectively. LDL, and its small (LDL1), medium (LDL2), and large (LDL3) subfractions, had mean values of 115.8 +/- 1.2 mg/dl, 8.3 +/- 0.4 mg/dl, 19.6 +/- 0.8 mg/dl, and 71.5 +/- 1.5 mg/dl, respectively. Bivariate analysis displayed significant genetic correlations between LDL subfractions and obesity-related factors: LDL1 with BMI (rhoG = 0.67, P < 0.05), waist (rhoG = 0.80, P < 0.001), and subscapular and tricep skinfolds (rhoG = 0.93, P < 0.005, and rhoG = 0.78, P < 0.05, respectively); LDL2 with BMI (rhoG = 0.52, P < 0.05), waist (rhoG = 0.46, P < 0.05), and tricep skinfold (rhoG = 0.60, P < 0.05); and mean LDL size with BMI (rhoG = -0.36), waist (rhoG = -0.42,), and subscapular and tricep skinfolds (rhoG = -0.44 and -0.43, respectively) (P < 0.005). These results show that a common set of genes is influencing LDL size and obesity-related factors in Alaskan Eskimos.
传统上属于低风险人群的阿拉斯加爱斯基摩人中心血管疾病发病率不断上升，令人担忧。本研究的目的是利用阿拉斯加原住民冠心病遗传学研究中最初954名参与者的数据，检验阿拉斯加爱斯基摩人低密度脂蛋白（LDL）亚组分与肥胖相关因素之间的遗传和环境相关性。使用SOLAR中实施的最大似然方差分量法计算遗传和环境影响估计值。体重、体重指数（BMI）和腰围的平均值分别为73.4±0.5千克、27.6±0.2千克/平方米和88.0±0.4厘米。LDL及其小（LDL1）、中（LDL2）和大（LDL3）亚组分的平均值分别为115.8±1.2毫克/分升、8.3±0.4毫克/分升、19.6±0.8毫克/分升和71.5±1.5毫克/分升。双变量分析显示LDL亚组分与肥胖相关因素之间存在显著的遗传相关性：LDL1与BMI（遗传相关系数rhoG = 0.67，P < 0.05）、腰围（rhoG = 0.80，P < 0.001）以及肩胛下和三头肌皮褶厚度（分别为rhoG = 0.93，P < 0.005和rhoG = 0.78，P < 0.05）；LDL2与BMI（rhoG = 0.52，P < 0.05）、腰围（rhoG = 0.46，P < 0.05）和三头肌皮褶厚度（rhoG = 0.60，P < 0.05）；LDL平均大小与BMI（rhoG = -0.36）、腰围（rhoG = -0.42）以及肩胛下和三头肌皮褶厚度（分别为rhoG = -0.44和-0.43）（P < 0.005）。这些结果表明，一组共同的基因正在影响阿拉斯加爱斯基摩人的LDL大小和肥胖相关因素。
