Picó Yolanda, Font Guillermina, Ruiz María José, Fernández Mónica
Laboratori de Bromatologia i Toxicologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, Spain.
Mass Spectrom Rev. 2006 Nov-Dec;25(6):917-60. doi: 10.1002/mas.20096.
Liquid chromatography-mass spectrometry (LC-MS) has become an invaluable technique for the control of pesticide residues to ensure food safety. After an introduction about the regulations that highlights its importance to meet the official requirements on analytical performance, the different mass spectrometers used in this field of research, as well as the LC-MS interfaces and the difficulties associated with quantitative LC-MS determination, are discussed. The ability to use practical data for quantifying pesticides together with the option of obtaining structural information to identify target and non-target parent compounds and metabolites are discussed. Special attention is paid to the impact of sample preparation and chromatography on the ionization efficiency of pesticides from food. The last section is devoted to applications from a food safety point of view. (c) 2006 Wiley Periodicals, Inc.
液相色谱 - 质谱联用（LC - MS）已成为控制农药残留以确保食品安全的一项极其重要的技术。在介绍了强调满足官方对分析性能要求的重要性的相关法规后，讨论了该研究领域中使用的不同质谱仪、LC - MS接口以及与LC - MS定量测定相关的困难。还讨论了利用实际数据定量农药的能力以及获取结构信息以鉴定目标和非目标母体化合物及代谢物的选项。特别关注了样品制备和色谱对食品中农药电离效率的影响。最后一部分从食品安全的角度介绍了相关应用。（c）2006年威利期刊公司
