Panjehpour Masoud, Overholt Bergein F
Center of Excellence for Treatment of Barrett's Esophagus, Thompson Cancer Survival Center, 1915 White Avenue, Knoxville, Tennessee 37916, USA.
Lasers Surg Med. 2006 Jun;38(5):390-5. doi: 10.1002/lsm.20367.
Porfimer sodium photodynamic therapy (ps-PDT) for Barrett's esophagus is a powerful endoscopic treatment that can eliminate high-grade dysplasia (HGD) and Barrett's mucosa and reduce the risk of development of cancer in these patients. Ps-PDT typically results in destruction of Barrett's esophagus in the majority of the treated area. However, residual small island of Barrett's mucosa may persist after PDT. Therefore, adjuvant thermal ablation should be available during follow-up endoscopies for ablation of residual islands of Barrett's mucosa. PDT should be applied concurrent with effective proton pump inhibitor therapy. This article provides a practical guide for application of porfimer sodium balloon PDT for management of Barrett's esophagus with HGD. Recommendations are provided for patient selection and screening, delivery of PDT to include light dosimetry, methodology for follow-up endoscopies, as well as discussing the potential side effects and complications.
用于巴雷特食管的卟吩姆钠光动力疗法（ps-PDT）是一种强大的内镜治疗方法，可消除高级别异型增生（HGD）和巴雷特黏膜，并降低这些患者发生癌症的风险。Ps-PDT通常会在大多数治疗区域导致巴雷特食管的破坏。然而，光动力疗法后可能会残留小的巴雷特黏膜岛。因此，在随访内镜检查期间应进行辅助热消融，以消融残留的巴雷特黏膜岛。PDT应与有效的质子泵抑制剂疗法同时应用。本文为应用卟吩姆钠球囊PDT治疗伴有HGD的巴雷特食管提供了实用指南。针对患者选择和筛查、PDT的实施（包括光剂量测定）、随访内镜检查方法以及讨论潜在的副作用和并发症提供了建议。
