三磷酸腺苷和二磷酸腺苷对大鼠及青蛙神经肌肉接头处神经传递的影响。
The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions.
作者信息
Ribeiro J A, Walker J
出版信息
Br J Pharmacol. 1975 Jun;54(2):213-8. doi: 10.1111/j.1476-5381.1975.tb06931.x.
Abstract
1 The effects of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) were investigated on evoked end-plate potentials (e.p.ps) and on miniature end-plate potentials (min. e.p.ps) recorded from muscle fibres of the rat diaphragm and the frog sartorius.2 ATP and ADP decreased the quantum content of the e.p.ps and the frequency of the min. e.p.ps. The maximum effects produced by the two substances were similar.3 The potency of ATP was found to be similar to that of adenosine. In the presence of adenosine, in a concentration producing its maximum effect, the addition of ATP had no further effect. This is compatible with the idea that ATP acts in the same way as adenosine.
摘要
研究了三磷酸腺苷（ATP）和二磷酸腺苷（ADP）对从大鼠膈肌和青蛙缝匠肌的肌纤维记录到的诱发终板电位（e.p.ps）和微小终板电位（min. e.p.ps）的影响。
ATP和ADP降低了e.p.ps的量子含量以及min. e.p.ps的频率。这两种物质产生的最大效应相似。
发现ATP的效力与腺苷相似。在存在产生最大效应浓度的腺苷时，添加ATP没有进一步的作用。这与ATP与腺苷以相同方式起作用的观点相符。
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