慢性抗精神病药物治疗对大鼠纹状体中多巴胺D2受体mRNA的上调作用。
Up-regulation of dopamine D2 receptor mRNA in rat striatum by chronic neuroleptic treatment.
作者信息
Rogue P, Hanauer A, Zwiller J, Malviya A N, Vincendon G
机构信息
Centre de Neurochimie du C.N.R.S., Strasbourg, France.
出版信息
Eur J Pharmacol. 1991 Jun 19;207(2):165-8. doi: 10.1016/0922-4106(91)90092-v.
PMID:1679015
Abstract
The effect of prolonged administration of antagonists on rat striatal dopamine D2 receptor binding and mRNA content was examined. Both haloperidol (2 and 4 mg/kg) and sulpiride (10 mg/kg) induced a significant rise in total D2 and D2(444) mRNA level and in Bmax. Regulation of messenger RNA accumulation is thus an important determinant of dopamine D2 receptor density.
摘要
研究了拮抗剂长期给药对大鼠纹状体多巴胺D2受体结合及mRNA含量的影响。氟哌啶醇（2和4mg/kg）和舒必利（10mg/kg）均使总D2和D2(444) mRNA水平及Bmax显著升高。因此，信使RNA积累的调节是多巴胺D2受体密度的一个重要决定因素。
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