Matsunaga T, Ohara K, Natsukari N, Fujita M
Department of Psychiatry, Hamamatsu University School of Medicine, Japan.
Neurosci Res. 1991 Nov;12(3):440-5. doi: 10.1016/0168-0102(91)90075-a.
Chronic treatment with haloperidol, a D2-receptor antagonist and a neuroleptic, increases the number of D2-receptors in rat striatum. However, there have been inconsistent reports on the D2-receptor mRNA level, one showing the increase in the mRNA level and another detecting no changes. Furthermore, they did not distinguish the two isoforms of D2-receptor, D2A and D2B. In the present work, both D2- and DeA-receptor mRNA levels in rat striatum were estimated after chronic administration of haloperidol. There was, within the sensitivity of the assay, no significant increase in either of them between 3 and 24 h after the last administration. This suggests that chronic haloperidol treatment does not affect the transcriptional regulation of the D2-receptor gene or the alternative splicing process of its transcripts.
用氟哌啶醇（一种D2受体拮抗剂和抗精神病药物）进行长期治疗会增加大鼠纹状体中D2受体的数量。然而，关于D2受体mRNA水平的报道并不一致，一份报告显示mRNA水平升高，另一份则未检测到变化。此外，他们没有区分D2受体的两种亚型，即D2A和D2B。在本研究中，在长期给予氟哌啶醇后，对大鼠纹状体中的D2受体和D2A受体mRNA水平进行了评估。在末次给药后3至24小时内，在检测灵敏度范围内，它们两者均未出现显著增加。这表明长期氟哌啶醇治疗不会影响D2受体基因的转录调控或其转录本的可变剪接过程。
