感染绵羊痂螨（绵羊疥癣螨）的绵羊对金黄色葡萄球菌和绵羊痒螨的免疫反应
Immune responses to Staphylococcus aureus and Psoroptes ovis in sheep infected with P. ovis--the sheep scab mite.
作者信息
Oliveira A M, MacKellar A, Hume L, Huntley J F, Thoday K L, van den Broek A H M
机构信息
The University of Edinburgh, Dermatology Unit, Division of Veterinary Clinical Sciences, The Hospital for Small Animals, Midlothian, EH25 9RG, UK.
出版信息
Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):64-72. doi: 10.1016/j.vetimm.2006.04.005. Epub 2006 Jun 21.
In sheep, lesions caused by Psoroptes ovis, the sheep scab mite, may become colonized by Staphylococcus aureus. The present study compares clinical signs, lesional area and the immune response to P. ovis and S. aureus in P. ovis-infested sheep with and without secondary S. aureus infection. No differences were detected in the clinical signs or lesional areas in the S. aureus-positive and -negative sheep. However, 6 weeks after infestation an IgG but not IgE isotype antibody response to S. aureus was detected in the S. aureus-positive but not the S. aureus-negative group of sheep. This response targeted S. aureus antigens with molecular weights of approximately 36, 38, 50 and 65 kDa. In addition, 6 weeks after infestation an IgE response to P. ovis was detected in the S. aureus-positive but not the S. aureus-negative group of sheep.
绵羊痒螨（Psoroptes ovis）引发的损伤可能会被金黄色葡萄球菌定植。本研究比较了有或无继发性金黄色葡萄球菌感染的绵羊痒螨感染绵羊，对绵羊痒螨和金黄色葡萄球菌的临床症状、损伤面积及免疫反应。在金黄色葡萄球菌阳性和阴性绵羊中，未检测到临床症状或损伤面积的差异。然而，感染6周后，在金黄色葡萄球菌阳性而非阴性绵羊组中检测到了针对金黄色葡萄球菌的IgG同型抗体反应，但未检测到IgE同型抗体反应。该反应针对分子量约为36、38、50和65 kDa的金黄色葡萄球菌抗原。此外，感染6周后，在金黄色葡萄球菌阳性而非阴性绵羊组中检测到了针对绵羊痒螨的IgE反应。
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