Rees L H, Grant D B, Wilson J
Br Med J. 1975 Jul 26;3(5977):201-2. doi: 10.1136/bmj.3.5977.201.
Raised plasma immunoreactive corticotrophin (ACTH) levels were found in five boys with the sex-linked disorder progressive leucodystrophy associated with adrenal insufficiency (Addison-Schilder's disease) and in a symptom-free brother of one of them. Similar ACTH concentrations were found using two antisera, one against the N-terminal part of the ACTH molecule and the other against the C-terminal part. In one patient the circulating ACTH had normal biological activity as measured using the cytochemical ACTH bioassay. Immunoreactive beta/-melanocyte-stimulating hormone was also determined in one patient and found to be raised.
在5名患有与肾上腺功能不全相关的性连锁疾病——进行性脑白质营养不良（艾迪生病 - 谢尔德病）的男孩以及其中一名男孩的无症状兄弟中，发现血浆免疫反应性促肾上腺皮质激素（ACTH）水平升高。使用两种抗血清检测到了相似的ACTH浓度，一种抗血清针对ACTH分子的N端部分，另一种针对C端部分。在一名患者中，使用细胞化学ACTH生物测定法测得循环中的ACTH具有正常的生物活性。还对一名患者的免疫反应性β-促黑素细胞激素进行了测定，发现其水平升高。
