Shilling Rebecca A, Bandukwala Hozefa S, Sperling Anne I
Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago MC 6076, 5841 S. Maryland Ave, Chicago, IL 60637, USA.
Clin Immunol. 2006 Oct;121(1):13-8. doi: 10.1016/j.clim.2006.04.574. Epub 2006 Jun 21.
The Inducible Costimulator molecule (ICOS), a member of the CD28 family of costimulatory molecules, was identified in 1999 as a molecule expressed primarily on activated human T cells. Induced upon activation, ICOS appears to be an ideal target for modifying T-cell-mediated immune responses. ICOS was also found to be highly expressed on germinal center T cells, suggesting that ICOS was involved in T:B cell interactions. While ICOS has subsequently been shown to be important for both Th1 and Th2 cell activation and effector function, a central role for ICOS in the generation and maintenance of humoral immunity is emerging. In this review, we summarize the evidence that the level of ICOS expression regulates T-cell-dependent B cell responses and propose a model for the role of ICOS in diseases characterized by dysregulated humoral immunity.
诱导共刺激分子（ICOS）是共刺激分子CD28家族的成员之一，于1999年被鉴定为主要在活化的人T细胞上表达的分子。ICOS在活化时被诱导表达，似乎是调节T细胞介导的免疫反应的理想靶点。还发现ICOS在生发中心T细胞上高度表达，提示ICOS参与T细胞与B细胞的相互作用。虽然ICOS随后被证明对Th1和Th2细胞的活化及效应功能均很重要，但ICOS在体液免疫的产生和维持中的核心作用正在显现。在本综述中，我们总结了ICOS表达水平调节T细胞依赖性B细胞反应的证据，并提出了一个关于ICOS在以体液免疫失调为特征的疾病中的作用的模型。
