Fedoroff Nina
Huck Institutes of the Life Sciences and Biology Department, Penn State University, University Park, PA 16803, USA.
Ann Bot. 2006 Aug;98(2):289-300. doi: 10.1093/aob/mcl128. Epub 2006 Jun 21.
Reactive oxygen species are produced in a highly localized and specific pattern in biological stress responses. The present review examines the redox regulatory aspects of a number of molecular stress response mechanisms in both prokaryotes and eukaryotes.
The present review provides examples representing both the cytoplasmic stress response, often studied as the heat shock response, as well as the stress response of the endoplasmic reticulum, known as the unfolded protein response. The examples have been selected to illustrate the variety of ways that redox signals mediate and affect stress responses.
Redox regulatory mechanisms are intricately embedded in both the cytoplasmic and endoplasmic reticulum stress responses at multiple levels. Many different stimuli, both internal and external, activate endogenous production of reactive oxygen species as a necessary part of the intracellular communication system that activates stress responses.
在生物应激反应中，活性氧以高度局部化和特定的模式产生。本综述研究了原核生物和真核生物中多种分子应激反应机制的氧化还原调节方面。
本综述提供了代表细胞质应激反应（通常作为热休克反应进行研究）以及内质网应激反应（称为未折叠蛋白反应）的示例。选择这些示例是为了说明氧化还原信号介导和影响应激反应的多种方式。
氧化还原调节机制在多个层面上错综复杂地嵌入细胞质和内质网应激反应中。许多不同的刺激，包括内部和外部刺激，都会激活活性氧的内源性产生，这是激活应激反应的细胞内通讯系统的必要组成部分。
