参与小肠结肠炎耶尔森菌全身感染的一种新型孔蛋白的特性分析
Characterization of a novel porin involved in systemic Yersinia enterocolitica infection.
作者信息
Mildiner-Earley Shirly, Miller Virginia L
机构信息
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
出版信息
Infect Immun. 2006 Jul;74(7):4361-5. doi: 10.1128/IAI.00154-06.
Abstract
Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a DeltasfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin.
摘要
小肠结肠炎耶尔森菌是一种能够在小鼠模型中引发全身性疾病的肠道病原体。我们鉴定出了一种新蛋白，即全身因子蛋白A（SfpA），它在其他致病细菌中保守存在且与全身性疾病有关。对细菌定殖的分析表明，ΔsfpA菌株在肠系膜淋巴结定殖方面存在缺陷。生物信息学和功能研究表明SfpA是一种孔蛋白。
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