脆性X智力低下蛋白与一种独特的mRNA核输出因子NXF2相互作用。
The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2.
作者信息
Lai Dongmei, Sakkas Denny, Huang Yingqun
出版信息
RNA. 2006 Aug;12(8):1446-9. doi: 10.1261/rna.94306. Epub 2006 Jun 21.
Abstract
Loss of fragile X mental retardation protein, FMRP, causes the fragile X syndrome. Highly expressed in the brain and testis, FMRP has been implicated in the transport and translation of specific mRNAs. Here we show that FMRP and the mRNA nuclear export factor NXF2 co-express in the mouse male germ cells and hippocampal neurons and that FMRP associates with NXF2 but not with its close relative NXF1. We thus hypothesize that FMRP and NXF2 may act in concert to promote the nucleocytoplasmic transport of specific mRNAs in male germ cells and neurons.
摘要
脆性X智力低下蛋白（FMRP）的缺失会导致脆性X综合征。FMRP在大脑和睾丸中高度表达，与特定mRNA的运输和翻译有关。我们在此表明，FMRP与mRNA核输出因子NXF2在小鼠雄性生殖细胞和海马神经元中共表达，且FMRP与NXF2相互关联，而不与其近亲NXF1相关联。因此，我们推测FMRP和NXF2可能协同作用，促进雄性生殖细胞和神经元中特定mRNA的核质运输。
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