Mehrotra R, Yadav S
Department of Pathology, Moti Lal Nehru Medical College, University of Allahabad, 16/2, Lowther Road, Allahabad - 211 002, India.
Indian J Cancer. 2006 Apr-Jun;43(2):60-6. doi: 10.4103/0019-509x.25886.
Tumours of the head and neck comprise an important group of neoplasia, the incidence of which is increasing in many parts of the world. This increase remains high, despite all the advances in modern medicine. This malignancy is more prevalent in the developing world and unfortunately, has not received satisfactory attention as the more prevalent cancers of the developed world, like lung, breast, or colon cancer. Recent advances in diagnosis and therapeutic techniques of these lesions have yielded novel molecular targets, uncovered signal pathway dominance and advanced early cancer detection. This review covers recent advances in our understanding of the etiology, molecular changes and the possible role that genomic and proteomic research might play in the diagnosis and effective cure of this modern-day scourge.
头颈部肿瘤是一组重要的肿瘤，在世界许多地区其发病率正在上升。尽管现代医学取得了诸多进展，但这一上升趋势仍然居高不下。这种恶性肿瘤在发展中世界更为普遍，不幸的是，与发达国家更为常见的癌症（如肺癌、乳腺癌或结肠癌）相比，它并未得到令人满意的关注。这些病变在诊断和治疗技术方面的最新进展产生了新的分子靶点，揭示了信号通路的主导地位，并推动了早期癌症检测。本综述涵盖了我们在病因学、分子变化以及基因组和蛋白质组学研究在诊断和有效治疗这一现代灾难中可能发挥的作用方面的最新认识进展。
