Center of Proteomic and Biochemical Analyses, Post-Graduation in Biotechnology and Genomical Sciences, Catholic University of Brasilia, Brasilia-DF, Brazil.
Cancer. 2010 Nov 1;116(21):4914-25. doi: 10.1002/cncr.25245.
Tumors of the head and neck comprise an important neoplasia group, the incidence of which is increasing in many parts of the world. Recent advances in diagnostic and therapeutic techniques for these lesions have yielded novel molecular targets, uncovered signal pathway dominance, and advanced early cancer detection. Proteomics is a powerful tool for investigating the distribution of proteins and small molecules within biological systems through the analysis of different types of samples. The proteomic profiles of different types of cancer have been studied, and this has provided remarkable advances in cancer understanding. This review covers recent advances for head and neck cancer; it encompasses the risk factors, pathogenesis, proteomic tools that can help in understanding cancer, and new proteomic findings in this type of cancer.
头颈部肿瘤是一组重要的肿瘤，在世界许多地区的发病率都在增加。这些病变的诊断和治疗技术的最新进展产生了新的分子靶点，揭示了信号通路的主导地位，并提高了早期癌症的检测水平。蛋白质组学是一种通过分析不同类型的样本来研究生物系统内蛋白质和小分子分布的强大工具。不同类型癌症的蛋白质组谱已经被研究过，这为癌症的认识提供了显著的进展。本综述涵盖了头颈部癌症的最新进展；包括危险因素、发病机制、有助于了解癌症的蛋白质组学工具以及这种癌症的新蛋白质组学发现。
