丙型肝炎病毒1型很少通过垂直传播，但在西非地区，婴儿期会感染该病毒。

GB virus C genotype 1 is rarely transmitted vertically but acquired during infancy in West Africa.

作者信息

Li Chengyao, Danso Kwabena, Addo-Yobo Emmanuel, Dompreh Albert, Sarkodie Francis, Owusu-Ofori Shirley, Allain Jean-Pierre

机构信息

Division of Transfusion Medicine, National Blood Service and University of Cambridge, UK.

出版信息

AIDS. 2006 Jun 26;20(10):1458-60. doi: 10.1097/01.aids.0000233583.02586.14.

DOI:10.1097/01.aids.0000233583.02586.14

PMID:16791024

Abstract

Paired Ghanaian plasma and cord blood from pregnant women, alongside plasma samples from children aged 1 day to 70 months, were tested for GBV-C, HIV-1 RNA loads and anti-E2. Frequency of GBV-C vertical transmission in West Africa is significantly lower than in Europe, the USA or East Asia where genotype 2 or 3 is prevalent. While horizontal transmission appears predominant in West Africa, the lower viral load of African genotype 1 might explain limited vertical transmission.

摘要

对加纳孕妇的配对血浆和脐带血，以及1日龄至70个月龄儿童的血浆样本进行了GBV-C、HIV-1 RNA载量和抗E2检测。在西非，GBV-C垂直传播的频率显著低于欧洲、美国或东亚，在这些地区2型或3型基因型较为普遍。虽然在西非水平传播似乎占主导地位，但非洲1型基因型较低的病毒载量可能解释了垂直传播有限的原因。