Shimizu H, Lee J D, Ogawa K B, Sugiyama T, Yamamoto M, Hara A, Nakamura T
First Department of Internal Medicine, Fukui Medical School, Japan.
Jpn Circ J. 1991 Jul;55(7):692-4. doi: 10.1253/jcj.55.692.
A 48-year-old man with severe variant angina refractory to conventional treatment with calcium antagonists and nitrates, or prazosin, or trihexyphenidyl hydrochloride, became symptom free rapidly when treated with denopamine, a adrenergic beta-1 agonist. Denopamine may prove to be an additional therapeutic agent in the management of severe variant angina. Therefore the response to denopamine and the lack of response to prazosin in this patient suggests that not only the adrenergic alpha receptor but also the adrenergic beta-1 receptor plays an important role in the production of coronary spasm, at least in some patients.
一名48岁男性，患有严重变异型心绞痛，对钙拮抗剂、硝酸盐、哌唑嗪或盐酸苯海索的常规治疗均无效，在接受β-1肾上腺素能激动剂多巴胺治疗后迅速症状消失。多巴胺可能被证明是治疗严重变异型心绞痛的一种额外治疗药物。因此，该患者对多巴胺的反应以及对哌唑嗪无反应表明，至少在某些患者中，不仅肾上腺素能α受体，而且肾上腺素能β-1受体在冠状动脉痉挛的发生中起重要作用。
