小鼠初级嗅觉通路中的去神经支配。II. 对肌肽和其他胺类化合物的影响。

Denervation in the primary olfactory pathway of mice. II. Effects on carnosine and other amine compounds.

作者信息

Ferriero D, Marogolis F L

出版信息

Brain Res. 1975 Aug 22;94(1):75-86. doi: 10.1016/0006-8993(75)90878-1.

Abstract

Carnosine (beta-alanyl-histidine) is present in the olfactory bulb and olfactory eqithelium of mice and rats at 1-2 nmole/mg tissue. Peripheral deafferentation or central denervation causes a rapid, selective decrease of this depeptide from the reciprocal portion of the primary olfactory pathway. These data demonstrate the localization of carnosine within the primary olfactory chemoreceptor neurons and suggest a possible role for this compound in neural transmission.

摘要

肌肽（β-丙氨酰组氨酸）以1-2纳摩尔/毫克组织的含量存在于小鼠和大鼠的嗅球及嗅上皮中。外周去传入神经或中枢去神经支配会导致该二肽在初级嗅觉通路的相应部分迅速、选择性地减少。这些数据证明了肌肽在初级嗅觉化学感受神经元中的定位，并表明该化合物在神经传递中可能发挥作用。