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肌肽在初级嗅觉通路中。

Carnosine in the primary olfactory pathway.

作者信息

Margolis F L

出版信息

Science. 1974 May 24;184(4139):909-11. doi: 10.1126/science.184.4139.909.

DOI:10.1126/science.184.4139.909
PMID:4825893
Abstract

Carnosine (beta-alanyl-L-histidine) is present in mouse olfactory bulbs and nasal olfactory epithelium at concentrations exceeding that previously reported for any brain region of any species. After peripheral deafferentation, carnosine concentrations in the olfactory bulbs decrease to less than 10 percent that of normal, while other amino compounds are unaffected. Carnosine appears to be highly localized to the primary olfactory pathway.

摘要

肌肽(β-丙氨酰-L-组氨酸)在小鼠嗅球和鼻嗅上皮中的浓度超过此前报道的任何物种任何脑区的浓度。外周去传入神经后,嗅球中的肌肽浓度降至正常浓度的10%以下,而其他氨基化合物未受影响。肌肽似乎高度定位于初级嗅觉通路。

相似文献

1
Carnosine in the primary olfactory pathway.肌肽在初级嗅觉通路中。
Science. 1974 May 24;184(4139):909-11. doi: 10.1126/science.184.4139.909.
2
Denervation in the primary olfactory pathway of mice. II. Effects on carnosine and other amine compounds.小鼠初级嗅觉通路中的去神经支配。II. 对肌肽和其他胺类化合物的影响。
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Denervation in the primary olfactory pathway of mice. III. Effect on enzymes of carnosine metabolism.小鼠初级嗅觉通路中的去神经支配。III. 对肌肽代谢酶的影响。
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Carnosine--an olfactory bulb peptide.肌肽——一种嗅球肽。
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Cellular localization of carnosine-like and anserine-like immunoreactivities in rodent and avian central nervous system.肌肽样和鹅肌肽样免疫反应性在啮齿动物和鸟类中枢神经系统中的细胞定位。
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Ligand binding studies in the mouse olfactory bulb: identification and characterization of a L-[3H]carnosine binding site.小鼠嗅球中的配体结合研究:L-[3H]肌肽结合位点的鉴定与表征
Brain Res. 1978 Dec 15;158(2):407-22. doi: 10.1016/0006-8993(78)90684-4.
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The subcellular distribution of carnosine, carnosine synthetase, and carnosinase in mouse olfactory tissues.肌肽、肌肽合成酶和肌肽酶在小鼠嗅觉组织中的亚细胞分布。
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[Immunohistochemical study on the primary olfactory neuron of rat and suncus].[大鼠和麝鼩初级嗅觉神经元的免疫组织化学研究]
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Carnosine-, calcitonin gene-related peptide- and tyrosine hydroxylase-immunoreactivity in the mouse olfactory bulb following peripheral denervation.外周去神经支配后小鼠嗅球中肌肽、降钙素基因相关肽和酪氨酸羟化酶免疫反应性
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Carnosine in primary afferents of the olfactory system: an autoradiographic and biochemical study.嗅觉系统初级传入纤维中的肌肽:放射自显影及生化研究
J Neurosci. 1982 Feb;2(2):244-55. doi: 10.1523/JNEUROSCI.02-02-00244.1982.

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Carnosine synthase deficiency is compatible with normal skeletal muscle and olfactory function but causes reduced olfactory sensitivity in aging mice.肉碱合成酶缺乏症与正常的骨骼肌和嗅觉功能兼容,但会导致老年小鼠的嗅觉敏感性降低。
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