SOX9和SOX10在中枢神经上皮肿瘤中的表达。
Expression of SOX9 and SOX10 in central neuroepithelial tumor.
作者信息
Kordes U, Hagel C
机构信息
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr 52, Hamburg, 20246, Germany.
出版信息
J Neurooncol. 2006 Nov;80(2):151-5. doi: 10.1007/s11060-006-9180-7. Epub 2006 Jun 22.
The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.
SOX E 族转录因子在星形胶质细胞和少突胶质细胞的特化与分化过程中发挥着不可或缺的作用。我们通过免疫组织化学方法检测了原发性脑肿瘤中SOX9和SOX10的表达模式。儿科和成人的高级别肿瘤（星形细胞瘤、少突胶质细胞瘤和原始神经外胚层肿瘤）中SOX9和SOX10均呈现强核染色。相比之下，儿科的毛细胞型星形细胞瘤表达的SOX9和SOX10要少得多。反应性星形胶质增生仅表现为SOX9的增加。
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