Stanton P K, Chattarji S, Sejnowski T J
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Neurosci Lett. 1991 Jun 10;127(1):61-6. doi: 10.1016/0304-3940(91)90895-z.
Recently, we have reported an associative long-term depression (LTD) of synaptic strength in hippocampal field CA1 that is produced when a low-frequency test input is negatively correlated in time with a high-frequency conditioning input. We have also found that pairing of synaptic activity with postsynaptic hyperpolarization is sufficient to induce LTD. We report here that 2-amino-3-phosphonopropionate (AP3), a selective inhibitor of phosphoinositide (PI) turnover mediated by the metabotropic glutamate receptor, blocks the induction of associative LTD in hippocampal field CA1, but does not impair the induction of LTP. Our data suggest that metabotropic glutamate receptor activation is involved in the induction of LTD.
最近，我们报道了海马体CA1区突触强度的联合性长时程抑制（LTD），当低频测试输入与高频条件输入在时间上呈负相关时会产生这种抑制。我们还发现，突触活动与突触后超极化配对足以诱导LTD。我们在此报告，2-氨基-3-膦酰丙酸（AP3）是一种由代谢型谷氨酸受体介导的磷酸肌醇（PI）周转的选择性抑制剂，它能阻断海马体CA1区联合性LTD的诱导，但不会损害长时程增强（LTP）的诱导。我们的数据表明，代谢型谷氨酸受体的激活参与了LTD的诱导。
