Izumi Y, Zorumski C F
Department of Psychiatry, Washington University Medical School, St. Louis, MO 63110.
Neurosci Lett. 1994 Jul 18;176(1):89-92. doi: 10.1016/0304-3940(94)90878-8.
The effects of 100 microM D,L-2-amino-3-phosphonopropionate (AP3), 100 microM D,L-2-amino-4-phosphonobutyric acid (AP4), and 500 microM (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.
在由15日龄、30日龄和60日龄大鼠制备的海马脑片CA1区，研究了100微摩尔D，L-2-氨基-3-膦酰丙酸（AP3）、100微摩尔D，L-2-氨基-4-膦酰丁酸（AP4）和500微摩尔（R，S）-α-甲基-4-羧基苯基甘氨酸（MCPG）（代谢型谷氨酸受体（mGluRs）介导的磷酸肌醇（PI）周转的抑制剂）对长时程增强（LTP）诱导的影响。在15日龄或30日龄大鼠中，强直刺激后立即施加5分钟的AP3和MCPG可抑制LTP。AP4的效果较差。所有抑制剂对60日龄大鼠的LTP均无效。这些数据支持以下假说：代谢型谷氨酸受体在LTP诱导中的作用受发育影响。
