Spence Michele M, Hui Rita, Chan James
Kaiser Permanente, 12254 Bellflower Blvd., Downey, CA 90242, USA.
J Manag Care Pharm. 2006 Jun;12(5):377-82. doi: 10.18553/jmcp.2006.12.5.377.
Generic-only pharmacy benefits may present more of a burden to patients with chronic disease conditions such as chronic obstructive pulmonary disease (COPD), where generic drug therapy choices are more limited.
To evaluate the strategies that elderly patients with COPD use to manage their out-of-pocket (OOP) prescription expenses in a generic-only pharmacy benefit compared with similar patients with a single-tier copayment or a 2-tier pharmacy benefit with coverage of brand formulary drugs.
Surveys were mailed to a sample of 3,000 Kaiser Permanente (California) patients (aged > or = 65 years) who had a diagnosis for COPD and received at least 1 prescription for a COPD-related medication during 2003. The sample was stratified by type of pharmacy benefit: generic-only, single copayment tier, and 2 copayment tiers. The survey contained questions about strategies used to reduce OOP prescription expenses, such as stop taking a prescribed medication, purchase prescriptions out of the country, or discuss OOP prescription expenses with a physician. The likelihood of using specific strategies to reduce OOP prescription expenses was modeled using logistic regression. Covariates included social support, quality of life, smoking status, socioeconomic status, total prescription costs, and demographics.
A total of 1,624 surveys were returned, for a 54% response rate. Results from logistic regressions indicate that COPD patients with a generic-only benefit are significantly more likely to report that they discussed their OOP costs with their physician (odds ratio [OR]=9.02; 95% confidence interval [CI], 6.15- 13.22), purchased their medications from another country (OR=6.70; 95% CI, 3.17-14.16) and reduced spending on food and clothing (OR=4.06; 95% CI, 2.70-6.12). They are also more likely to report that they had taken less than the prescribed amount of a regular medication (OR=1.70; 95% CI, 1.25-2.31) and that they stopped taking one or more of their regular medications (OR=1.77; CI, 1.27-2.47). Patients with low annual household incomes (<25,000 US dollars) were significantly more likely to discuss their OOP costs with their physician (OR=1.47; 95% CI, 1.08-2.00 ) and to reduce spending on food and clothing (OR=1.97; 95% CI, 1.42-2.73) than those with higher incomes. Approximately 15% of COPD patients obtained drug samples from their physicians as a method to reduce OOP costs, and there was no difference among the 3 groups in the prevalence of this cost management strategy. Overall, patients in the generic-only pharmacy benefit used an average of 3 methods to reduce OOP pharmacy costs compared with approximately 1.5 cost reduction methods used by patients in single-tier and 2-tier copayment designs who had coverage of formulary brand as well as generic drugs.
Elderly patients with COPD and a generic-drug-only pharmacy benefit are more likely to report using a variety of strategies to reduce their OOP costs compared with similar patients with single-tier copayment or 2-tier copayment pharmacy benefits. The most common strategy was discussing OOP costs with their physician, and use of this strategy was inversely related to household income. There was no difference in the proportion of COPD patients among the 3 pharmacy benefit groups that used drug samples from their physicians as a means to reduce OOP costs.
仅提供通用名药物的药房福利可能给患有慢性疾病(如慢性阻塞性肺疾病,COPD)的患者带来更多负担,因为这些患者可选择的通用名药物治疗方案更为有限。
评估患有COPD的老年患者在仅提供通用名药物的药房福利下,与具有单层共付额或双层药房福利(涵盖品牌药物处方集)的类似患者相比,用于管理自付处方费用的策略。
向3000名凯撒医疗集团(加利福尼亚州)的患者(年龄≥65岁)邮寄调查问卷,这些患者被诊断患有COPD,并在2003年期间至少接受过1次与COPD相关药物的处方。样本按药房福利类型分层:仅通用名药物、单层共付额、双层共付额。该调查包含有关用于减少自付处方费用的策略的问题,例如停止服用处方药、从国外购买处方、或与医生讨论自付处方费用。使用逻辑回归对使用特定策略减少自付处方费用的可能性进行建模。协变量包括社会支持、生活质量、吸烟状况、社会经济地位、总处方费用和人口统计学特征。
共回收1624份调查问卷,回复率为54%。逻辑回归结果表明,仅享受通用名药物福利的COPD患者更有可能报告他们与医生讨论了自付费用(优势比[OR]=9.02;95%置信区间[CI],6.15 - 13.22),从另一个国家购买药物(OR=6.70;95%CI,3.17 - 14.16),并减少食品和衣物支出(OR=4.06;95%CI,2.70 - 6.12)。他们也更有可能报告服用的常规药物剂量少于规定剂量(OR=1.70;95%CI,1.25 - 2.31)以及停止服用一种或多种常规药物(OR=1.77;CI,1.27 - 2.47)。家庭年收入低(<25,000美元)的患者比高收入患者更有可能与医生讨论自付费用(OR=1.47;95%CI,1.08 - 2.00)并减少食品和衣物支出(OR=1.97;95%CI,1.42 - 2.73)。约15%的COPD患者从医生处获取药物样本作为减少自付费用的一种方法,在这一费用管理策略的患病率方面,三组之间没有差异。总体而言,仅享受通用名药物药房福利的患者平均使用3种方法来减少自付药房费用,而单层和双层共付额设计且涵盖品牌药物处方集以及通用名药物的患者平均使用约1.5种费用降低方法。
与具有单层共付额或双层共付额药房福利的类似患者相比,患有COPD且仅享受通用名药物药房福利的老年患者更有可能报告使用多种策略来降低自付费用。最常见的策略是与医生讨论自付费用,且该策略的使用与家庭收入呈负相关。在使用医生提供的药物样本作为降低自付费用手段的COPD患者比例方面,三个药房福利组之间没有差异。