Nair B S, Erickson J R, Pillai R, Estrada A, Watson R R
Department of Family and Community Medicine, University of Arizona, Tucson 85724.
Toxicol Lett. 1991 Aug;57(3):339-45. doi: 10.1016/0378-4274(91)90208-n.
The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.
对47名有多种药物和酒精滥用史的受试者的T细胞E玫瑰花结形成情况进行了研究，并与15名正常对照者进行了比较。总玫瑰花结形成细胞（TRFC）数量没有明显变化。然而，活性和高亲和力玫瑰花结形成细胞（ARFC和HARFC）数量减少。这两个携带CD2抗原的T细胞亚群被认为是具有免疫活性的监测细胞。因此，与它们相关的异常可能是由于药物滥用的联合免疫毒性作用，调节了吸毒者的免疫状态。
