人胎儿组织中CD2-/CD3+ T细胞的鉴定。
Identification of CD2-/CD3+ T cells in fetal human tissue.
作者信息
Kabelitz D, Conradt P
机构信息
Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.
出版信息
J Exp Med. 1988 Nov 1;168(5):1941-6. doi: 10.1084/jem.168.5.1941.
Abstract
From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep erythrocytes. These results show that (a) significant numbers of CD2-/3+ T cells are present in fetal human spleen and/or thymus; and (b) in contrast to the widely accepted view, expression of CD2 is not a prerequisite for the expression of the CD3 molecular complex on human T cells.
摘要
在妊娠第20至24周的人类胎儿脾脏或胸腺细胞中，发现有1%至23%表现出一种先前未被识别的CD2-/CD3+表型。依赖白细胞介素-2的CD2-/3+ T细胞长期克隆体不与一组抗CD2单克隆抗体发生反应，也不与绵羊红细胞形成玫瑰花结。这些结果表明：(a) 人类胎儿脾脏和/或胸腺中存在大量CD2-/3+ T细胞；(b) 与广泛接受的观点相反，CD2的表达并非人类T细胞上CD3分子复合物表达的先决条件。
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