Lee Shin-Da, Huang Chih-Yang, Shu Wen-Tong, Chen Ter-Hsin, Lin James A, Hsu Hsi-Hsien, Lin Chung-Sheng, Liu Chung-Jung, Kuo Wei-Wen, Chen Li-Mien
School of Physical Therapy, Chung-Shan Medical University, Taichung, Taiwan.
Clin Chim Acta. 2006 Aug;370(1-2):50-6. doi: 10.1016/j.cca.2006.01.012. Epub 2006 Jun 21.
Serum iron overload or iron deficiency appears to be associated with atherosclerosis and ischemic myocardial damage. Roles of low or high serum iron in patients with ischemic heart diseases are still controversial.
Serum samples for biochemical and immunologic analyses were collected from the 73 normal subjects and the 90 patients with ischemic heart disease (IHD), the latter of which were selected from 142 patients and classified by low, normal and high serum iron.
Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), high sensitive C-Reactive protein (hsCRP), and interleukin-10 (IL-10) were increased and insulin-like growth factor (IGF)-I was decreased in IHD patients with low serum iron, whereas these parameters were not changed in IHD patients with normal or high serum iron, compared with normal subjects. Total bilirubin was increased in IHD patients with high serum iron but was not changed in IHD patients with low or normal serum iron, compared with normal subjects.
The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I. These findings may imply that IHD patients with low serum irons were associated with less cardiac protection and more pro-inflammatory states than normal subjects or IHD patients with either normal or high serum iron.
血清铁过载或铁缺乏似乎与动脉粥样硬化和缺血性心肌损伤有关。血清铁水平低或高在缺血性心脏病患者中的作用仍存在争议。
收集73名正常受试者和90名缺血性心脏病（IHD）患者的血清样本进行生化和免疫分析，后者从142名患者中选取，并根据血清铁水平低、正常和高进行分类。
与正常受试者相比，血清铁水平低的IHD患者中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、高敏C反应蛋白（hsCRP）和白细胞介素-10（IL-10）升高，胰岛素样生长因子（IGF）-I降低，而血清铁水平正常或高的IHD患者这些参数无变化。与正常受试者相比，血清铁水平高的IHD患者总胆红素升高，但血清铁水平低或正常的IHD患者总胆红素无变化。
血清铁水平低的IHD患者与促炎状态相关，如TNF-α、IL-6和hsCRP升高；抗炎活性增加，如IL-10升高；心脏保护因子降低，如IGF-I降低。这些发现可能意味着血清铁水平低的IHD患者与正常受试者或血清铁水平正常或高的IHD患者相比，心脏保护作用较小且促炎状态更多。
