Jansen Jacobus F A, Aldenkamp Albert P, Marian Majoie H J, Reijs Rianne P, de Krom Marc C T F M, Hofman Paul A M, Eline Kooi M, Nicolay Klaas, Backes Walter H
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Epilepsy Behav. 2006 Aug;9(1):181-5. doi: 10.1016/j.yebeh.2006.05.004. Epub 2006 Jun 21.
Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.
采用功能性磁共振成像技术对隐蔽性词语生成进行研究，以检查癫痫患者中与托吡酯诱导的认知语言障碍相关的脑激活异常情况。与癫痫对照组相比，托吡酯治疗组前额叶皮质语言介导区域的激活明显较少；托吡酯组的神经心理学语言评分也显著较低。这些发现表明，托吡酯对介导表达性语言的大脑神经系统有重要影响。
