Schneider Jennifer J, Good Phillip, Ravenscroft Peter J
School of Biomedical Sciences (J.J.S.), Faculty of Health, and Faculty of Medical Practice and Population Health (P.G., P.J.R.), University of Newcastle, Callaghan, Australia.
J Pain Symptom Manage. 2006 Jun;31(6):563-7. doi: 10.1016/j.jpainsymman.2005.09.008.
Previous studies have reported loss of clonazepam from solutions administered intravenously from plastic infusion bags and administration sets. In palliative care, clonazepam is sometimes administered through syringe drivers using polyvinyl chloride (PVC) infusion tubing. No data currently exist to show whether use of PVC tubing affects the amount of clonazepam actually received by the patient. This study compared the use of two different types of PVC tubing with a non-PVC tubing. Solutions containing clonazepam or clonazepam and morphine were prepared with either normal saline or water for injection as diluent. Concentrations of morphine and clonazepam were determined using high-performance liquid chromatography. Significant loss of clonazepam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used.
先前的研究报告称，从塑料输液袋和输液器静脉给药的溶液中氯硝西泮会有所损失。在姑息治疗中，氯硝西泮有时会通过使用聚氯乙烯（PVC）输液管的注射器泵给药。目前尚无数据表明使用PVC输液管是否会影响患者实际接收的氯硝西泮量。本研究比较了两种不同类型的PVC输液管与一种非PVC输液管的使用情况。含有氯硝西泮或氯硝西泮与吗啡的溶液分别用生理盐水或注射用水作为稀释剂配制。使用高效液相色谱法测定吗啡和氯硝西泮的浓度。在通过PVC输液管输注的所有溶液中均观察到氯硝西泮有显著损失（高达50%）。通过非PVC输液管输注的溶液中氯硝西泮的初始浓度保留率大于90%。建议在使用注射器泵给药氯硝西泮时，使用非PVC输液管。
