[人I型和II型子宫内膜癌基因表达谱的初步研究]
[Preliminary study of gene expression profiling in human type I and II endometrial carcinoma].
作者信息
Guo Sui-qun, Xing Fu-qi, Pang Zhan-jun, Fang Wei-yi, Liu Guo-bing
机构信息
Department of Gynaecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):734-7.
OBJECTIVE
To study gene expression profiling in human type I and II endometrial carcinoma.
METHODS
Six Affymetrix human genome genechips were utilized to investigate the differences in gene expression profiles between type I and II endometrial carcinoma with bioinformatic analysis.
RESULTS
Many genes were highly expressed in estrogen-dependent endometrial carcinoma, and some of them were involved in the metabolism and conversion of estrogen, while some others in estrogen regulation. CYP2C9, for instance, was involved in the conversion of estrogen sulfate to 16-hydroxy sulfate metabolite, DDC in estrogen-dependent pathogenesis of endometrial carcinoma possibly by DDC interaction with AR to enhance steroid receptor transcription.
CONCLUSION
High expression of these genes in estrogen-dependent endometrial carcinoma may provide insights into their roles in the pathogenesis and prognosis of this malignancy.
目的
研究人类I型和II型子宫内膜癌的基因表达谱。
方法
使用六张Affymetrix人类基因组基因芯片，通过生物信息学分析研究I型和II型子宫内膜癌之间基因表达谱的差异。
结果
许多基因在雌激素依赖型子宫内膜癌中高表达，其中一些参与雌激素的代谢和转化，另一些参与雌激素调节。例如，CYP2C9参与硫酸雌激素向16-羟基硫酸代谢物的转化，DDC可能通过与AR相互作用增强类固醇受体转录，从而在子宫内膜癌的雌激素依赖发病机制中发挥作用。
结论
这些基因在雌激素依赖型子宫内膜癌中的高表达可能为了解它们在这种恶性肿瘤的发病机制和预后中的作用提供线索。
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