Quan Xian-yue, Xie Wei, Zhang Xue-lin, Sun Xi-jie, Zhu Xing-li, Yan Zheng, Liang Wen
Imaging Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):747-9.
To improve the method for preparing rabbit VX2 liver tumor model and observe the magnetic resonance imaging (MRI) features of the implanted tumors.
Sixteen adult New Zealand white rabbits were assigned randomly into 4 equal groups, and VX2 tumor tissues were implanted into the right and left liver lobes with spiral CT guidance. Plain and contrast-enhanced MR scan and pathological analysis were performed in different stages (14, 18, 22 and 26 days) after tumor implantation.
Tumor implantation was successful in all the rabbits, and 18 to 22 days after tumor implantation, the diameters of the tumor ranged from 1 to 2 cm, which allowed observation and study. In plain MR scans, lower or equivalent tumor signal in comparison with hepatic parenchyma was observed, and contrast-enhanced scans produced obvious enhancement of the tumor edges. At 22 days after tumor implantation, obvious necrosis was observed in the center of the tumor.
This method of preparing rabbit VX2 liver tumor model with spiral CT guidance is simple and convenient, and the tumors can be observed effectively with dynamic plain and contrast-enhanced MR scans.
改进兔VX2肝肿瘤模型的制备方法，并观察植入肿瘤的磁共振成像（MRI）特征。
将16只成年新西兰白兔随机分为4组，在螺旋CT引导下将VX2肿瘤组织植入左右肝叶。在肿瘤植入后的不同阶段（14、18、22和26天）进行平扫及增强磁共振扫描和病理分析。
所有兔子肿瘤植入均成功，肿瘤植入后18至22天，肿瘤直径为1至2厘米，便于观察和研究。在磁共振平扫中，观察到肿瘤信号低于或等同于肝实质，增强扫描显示肿瘤边缘明显强化。肿瘤植入后22天，肿瘤中心观察到明显坏死。
这种在螺旋CT引导下制备兔VX2肝肿瘤模型的方法简单方便，通过动态平扫及增强磁共振扫描可有效观察肿瘤。
