Papies B, Schimke I, Moritz V, Massow S, Foerster D, Wagenknecht C
Department of Pathology and Clinical Biochemistry, Humboldt University, Berlin, Germany.
Prostaglandins Leukot Essent Fatty Acids. 1991 Jun;43(2):111-7. doi: 10.1016/0952-3278(91)90181-4.
In this study the influence of long-term feeding of an alpha-linolenic acid (LNA) enriched diet on the sensitivity of SHR to catecholamine-induced myocardial injury was investigated. An enhanced ischemic vulnerability after LNA supplementation was observed as indicated both by a marked decrease of enzyme activities in the myocardium and by a pronounced elevation of plasma enzymes. Distinctly higher TBARS levels in heart tissue and plasma of LNA rich fed SHR suggest that an exaggerated lipid peroxidation might contribute to the increased ischemic vulnerability. Non-enzymatic lipid peroxidation is favoured by a feeding-provoked enrichment in highly unsaturated fatty acids in tissue phospholipids. Under such conditions of enhanced substrate availability for radical-induced lipid peroxidation an increased requirement for antioxidants can be assumed which might not sufficiently be met by tocopherol-supplementation in SHR because of their known defects in antioxidative defense mechanisms.
在本研究中，研究了长期喂食富含α-亚麻酸（LNA）的饮食对自发性高血压大鼠（SHR）对儿茶酚胺诱导的心肌损伤敏感性的影响。补充LNA后缺血易损性增强，这通过心肌中酶活性的显著降低和血浆酶的明显升高得以体现。富含LNA的饮食喂养的SHR心脏组织和血浆中明显更高的硫代巴比妥酸反应产物（TBARS）水平表明，过度的脂质过氧化可能导致缺血易损性增加。组织磷脂中因喂食导致的高度不饱和脂肪酸富集有利于非酶促脂质过氧化。在自由基诱导的脂质过氧化底物可利用性增强的这种条件下，可以假定对抗氧化剂的需求增加，而由于SHR已知的抗氧化防御机制缺陷，补充生育酚可能无法充分满足这一需求。
