Pawlik W W, Hottenstein O D, Jacobson E D
Department of Medicine, University of Colorado School of Medicine, Denver 80262.
Am J Physiol. 1991 Sep;261(3 Pt 1):G392-400. doi: 10.1152/ajpgi.1991.261.3.G392.
The hypothesis was tested that peripheral, adrenergic nerves modulate reactive hyperemia (RH) in the intestinal circulation. In anesthetized rats, anterior mesenteric arterial occlusion for 30-120 s elicited subsequent RH responses, including 63-118% increases in the velocity of arterial blood flow, even greater increases in conductance, and durations of 64-139 s. The longer the period of arterial occlusion, the greater the magnitude of RH. Electrical stimulation of postganglionic, sympathetic nerves reduced RH responses in a frequency-dependent manner. RH responses were enhanced by pretreatment with hexamethonium and phenoxybenzamine and were diminished by pretreatment with propranolol. Propranolol also prevented the enhanced RH responses caused by hexamethonium and phenoxybenzamine. Reserpine prevented the enhanced RH responses to hexamethonium, but bilateral adrenalectomy did not. These findings support the hypothesis that peripheral sympathetic nerves modulate RH in rat gut, with alpha-adrenergic receptors restricting and beta-adrenergic receptors enhancing the hyperemia.
该假说认为，外周肾上腺素能神经调节肠道循环中的反应性充血（RH）。在麻醉大鼠中，肠系膜前动脉闭塞30 - 120秒会引发随后的RH反应，包括动脉血流速度增加63 - 118%，电导增加幅度更大，持续时间为64 - 139秒。动脉闭塞时间越长，RH的幅度越大。电刺激节后交感神经以频率依赖的方式降低RH反应。六甲铵和酚苄明预处理可增强RH反应，而普萘洛尔预处理则减弱RH反应。普萘洛尔还可预防六甲铵和酚苄明引起的增强的RH反应。利血平可预防六甲铵引起的增强的RH反应，但双侧肾上腺切除则无此作用。这些发现支持以下假说：外周交感神经调节大鼠肠道中的RH，α - 肾上腺素能受体限制充血，而β - 肾上腺素能受体增强充血。
