Takagi T, Naruse S, Shionoya S
First Department of Surgery, Nagoya University School of Medicine, Japan.
Am J Physiol. 1988 Oct;255(4 Pt 1):G522-8. doi: 10.1152/ajpgi.1988.255.4.G522.
Celiac and superior mesenteric arterial blood flows were measured simultaneously in conscious beagle dogs. The responses to food were completely different between the two arteries. Celiac flow increased quickly to 180-200% of the control 2 min after food but started to decline rapidly to preprandial levels, though greater than 90% of food was still in the stomach. It remained at preprandial levels over the next 1-6 h. Superior mesenteric flow increased gradually in 20-50 min (peak: 230%) and remained above the control levels for 3-6 h. The celiac response was inhibited by vagal block, hexamethonium, and gastric mucosal anesthesia by oxethazaine but not by atropine, phenoxybenzamine, or propranolol. Postprandial superior mesenteric hyperemia was blocked by mucosal anesthesia and was reduced by atropine by 80%. Ganglionic or adrenergic blockades were without effect. It is concluded that the celiac peak response to food is mediated by a nonadrenergic, noncholinergic vagal reflex in conscious dogs. Extrinsic nerves probably play little part in the postprandial increase of superior mesenteric flow.
在清醒的比格犬身上同时测量腹腔动脉和肠系膜上动脉的血流量。两条动脉对食物的反应完全不同。进食后2分钟，腹腔动脉血流量迅速增加至对照值的180% - 200%，但随后开始迅速下降至餐前水平，尽管此时超过90%的食物仍在胃中。在接下来的1 - 6小时内，其血流量维持在餐前水平。肠系膜上动脉血流量在20 - 50分钟内逐渐增加（峰值为230%），并在3 - 6小时内维持在对照水平之上。腹腔动脉的反应可被迷走神经阻滞、六甲铵及奥昔卡因的胃黏膜麻醉所抑制，但不受阿托品、酚苄明或普萘洛尔的影响。餐后肠系膜上动脉充血可被黏膜麻醉所阻断，阿托品可使其减少80%。神经节或肾上腺素能阻滞剂对此无作用。得出的结论是，清醒犬对食物的腹腔动脉峰值反应是由非肾上腺素能、非胆碱能的迷走神经反射介导的。外在神经可能在餐后肠系膜上动脉血流量增加中起很小的作用。
