Lane H A, Grace F, Smith J C, Morris K, Cockcroft J, Scanlon M F, Davies J S
Department of Endocrinology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, Wales, UK.
Eur J Clin Invest. 2006 Jul;36(7):483-8. doi: 10.1111/j.1365-2362.2006.01667.x.
Anabolic androgenic steroids are used by some bodybuilders to enhance performance. While the cardiovascular implications of supraphysiological androgen levels requires further clarification, use is associated with sudden death, left ventricular hypertrophy, thrombo-embolism and cerebro-vascular events.
To further understand the effect of androgenic anabolic steroid abuse on vascular function, this study assessed vascular stiffness (pulse-wave analysis) and cardiovascular risk factors in 28 male, bodybuilding subjects, of whom ten were actively receiving anabolic agents (group A; 26.4 +/- 7.2 years) and eight had undergone a 3-month "wash-out" period (group B; 32.1 +/- 7.1 years). The remaining ten bodybuilding subjects (group C; 24.4 +/- 4.4 years) denied any past use of anabolic steroids or other performance enhancing drugs. Comparisons were made with ten sedentary male controls (group D, 29.3 +/- 4.7 years).
Endothelial independent dilatation in response to glycerol trinitrate was significantly impaired in the group currently using anabolic steroids (group A) compared with the other three groups [A (5.63 +/- 3.24%) versus; B (11.10 +/- 4.91%), C (17.88 +/- 9.2%) and D (14.46 +/- 3.9%), P < 0.0005, respectively], whereas no significant differences in endothelial-dependent dilatation were detected between the groups [A (5.0 +/- 3.0%), B (7.4 +/- 3.4%), C (9.6 +/- 4.5%) and D (8.2 +/- 3.3%), P < 0.059, respectively].
Previous studies described a decline in vascular reactivity occurring in bodybuilding subjects which is independent of anabolic steroid use and may result from smooth muscle hypertrophy with increased vascular stiffness. This study revealed impaired vascular reactivity associated with anabolic agents and that improvement in vascular function may occur following their discontinuation.
一些健美运动员使用合成代谢雄激素类固醇来提高成绩。虽然超生理水平雄激素对心血管的影响仍需进一步阐明，但使用该类药物与猝死、左心室肥厚、血栓栓塞和脑血管事件有关。
为进一步了解合成代谢雄激素类固醇滥用对血管功能的影响，本研究评估了28名男性健美受试者的血管僵硬度（脉搏波分析）和心血管危险因素，其中10名正在接受合成代谢药物治疗（A组；26.4±7.2岁），8名经过了3个月的“洗脱期”（B组；32.1±7.1岁）。其余10名健美受试者（C组；24.4±4.4岁）否认既往使用过合成代谢类固醇或其他提高成绩的药物。将其与10名久坐不动的男性对照组（D组，29.3±4.7岁）进行比较。
与其他三组相比，目前正在使用合成代谢类固醇的组（A组）对硝酸甘油的内皮非依赖性舒张功能明显受损[A组（5.63±3.24%）对比；B组（11.10±4.91%）、C组（17.88±9.2%）和D组（14.46±3.9%），P分别<0.0005]，而各组之间在内皮依赖性舒张方面未检测到显著差异[A组（5.0±3.0%）、B组（7.4±3.4%）、C组（9.6±4.5%）和D组（8.2±3.3%），P分别<0.059]。
先前的研究描述了健美受试者中发生的血管反应性下降，这与合成代谢类固醇的使用无关，可能是由于平滑肌肥大伴血管僵硬度增加所致。本研究揭示了与合成代谢药物相关的血管反应性受损，并且在停药后血管功能可能会改善。
