Werner N, Nickenig G
Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Germany.
J Cell Mol Med. 2006 Apr-Jun;10(2):318-32. doi: 10.1111/j.1582-4934.2006.tb00402.x.
Bone marrow-derived circulating endothelial progenitor cells have been successfully used to enhance angiogenesis after tissue ischemia. The role of endothelial progenitor cells in endothelial cell homeostasis and their putative role in atherogenesis have been recently investigated. Cardiovascular risk factors negatively influence endothelial progenitor cell number and function while vasculoprotection e.g. by statins, estrogens and physical activity may be partly mediated by progenitor cells. Endogenous mobilization or injection of ex-vivo generated endothelial progenitor cells is associated with an enhanced reendothelialization, an improvement of endothelial function and reduced atherosclerotic burden. In contrast, endothelial progenitor cells may promote plaque angiogenesis in animal models and may negatively influence plaque development and stability. However, in humans with coronary atherosclerotic disease, endothelial progenitor cells are a novel risk predictor for cardiovascular mortality and morbidity. In this review we focus on the role of circulating endothelial progenitor cells in endothelial cell repair mechanisms at the vascular wall and their potentially protective and therapeutic role in atherosclerotic disease.
骨髓来源的循环内皮祖细胞已成功用于增强组织缺血后的血管生成。最近，人们对内皮祖细胞在内皮细胞稳态中的作用及其在动脉粥样硬化发生中的假定作用进行了研究。心血管危险因素会对内皮祖细胞的数量和功能产生负面影响，而血管保护作用，如他汀类药物、雌激素和体育活动的作用，可能部分是由祖细胞介导的。内源性动员或注射体外生成的内皮祖细胞与增强再内皮化、改善内皮功能和减轻动脉粥样硬化负担有关。相反，内皮祖细胞可能会促进动物模型中的斑块血管生成，并可能对斑块发展和稳定性产生负面影响。然而，在患有冠状动脉粥样硬化疾病的人类中，内皮祖细胞是心血管死亡率和发病率的一种新型风险预测指标。在这篇综述中，我们重点关注循环内皮祖细胞在血管壁内皮细胞修复机制中的作用及其在动脉粥样硬化疾病中潜在的保护和治疗作用。
