Liu Xin, Dai Pu, Huang De-liang, Yuan Hui-jun, Li Wei-min, Cao Ju-yang, Yu Fei, Zhang Rui-ning, Lin Hong-yan, Zhu Xiu-hui, He Yong, Yu You-jun, Yao Kun
Department of Otolaryngology, General Hospital of People's Liberation Army, Beijing 100853, China.
Zhonghua Yi Xue Za Zhi. 2006 May 23;86(19):1318-22.
To explore the necessity of large-scale screening of mtDNA A1555G mutation in prevention of aminoglycoside antibiotic induced deafness (AAID) and to develop a feasible method to prevent AAID.
A total of 1836 patients with non-syndromic hearing impairment (NSHI), 1352 students of schools for deaf-mutes in 11 provinces and municipality in China, 413 out-patients, and 71 persons from the families with maternal relatives suffering from AAID, underwent questionnaire survey and/or PCR for A-to-G mutation at nucleotide 1555 of the mitochondrial genome.
Sixty three patients with mtDNA A1555G mutation were found among the 1836 NSHI patients. Fifty-two maternal pedigrees were identified. 536 cases with normal hearing from these pedigrees were informed to avoid using aminoglycoside antibiotics (AmAn).
Large-scale screening of mtDNA A1555G mutation and relevant health education to avoid use of AmAn are effective to prevent ototoxicity in the A1555G carriers and their maternal relatives.
探讨大规模筛查线粒体DNA A1555G突变在预防氨基糖苷类抗生素致聋（AAID）中的必要性，并建立一种可行的预防AAID的方法。
对1836例非综合征性听力障碍（NSHI）患者、中国11个省直辖市1352名聋哑学校学生、413例门诊患者以及71名有母系亲属患AAID的家庭人员进行问卷调查和/或线粒体基因组第1555位核苷酸A到G突变的聚合酶链反应（PCR）检测。
在1836例NSHI患者中发现63例线粒体DNA A1555G突变患者。确定了52个母系家系。告知这些家系中536例听力正常者避免使用氨基糖苷类抗生素（AmAn）。
大规模筛查线粒体DNA A1555G突变并进行相关健康教育以避免使用AmAn，对预防A1555G携带者及其母系亲属的耳毒性有效。
