Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H
Division of Clinical Chemistry and Folkhälsan Research Center, Institute for Preventive Nutrition, Medicine and Cancer, Biomedicum, P.O. Box 63, FIN-00014 University of Helsinki, Finland.
Fitoterapia. 2006 Jul;77(5):358-66. doi: 10.1016/j.fitote.2006.05.017. Epub 2006 May 24.
Methanolic extracts (25 microug/ml) of species belonging to the genera of Combretum, Terminalia and Pteleopsis, collected during a field expedition in Tanzania in 1999, were screened for their antiproliferative and cytotoxic effects against three human cancer cell lines (HeLa, cervical carcinoma; T 24, bladder carcinoma; and MCF 7, breast carcinoma). A leaf extract of Combretum fragrans and a fruit extract of C. zeyheri gave the strongest antiproliferative and cytotoxic effects of all the twenty-four extracts screened in this investigation. In contrast to the highly powerful leaf extract of C. fragrans, the root extract of this species gave no cytotoxic effects against the investigated cancer cell lines at a concentration of 25 microg/ml. The other investigated species of Combretum and Terminalia differed greatly in their cytotoxic potential. Root extracts of Terminalia sambesiaca and T. sericea gave the strongest cytotoxic effects of the five species of Terminalia used in this study. Eight of the twenty-four investigated plant extracts showed pronounced cytotoxic effects (<30% proliferation compared to the control) against the T 24 bladder cancer cells, seven against the HeLa cells and four against the MCF 7 cells.
1999年在坦桑尼亚进行实地考察期间收集的风车子属、榄仁树属和假翼榄属植物的甲醇提取物（25微克/毫升），针对三种人类癌细胞系（HeLa，子宫颈癌；T 24，膀胱癌；以及MCF 7，乳腺癌）进行了抗增殖和细胞毒性作用筛选。在本次研究筛选的24种提取物中，风车子叶提取物和泽氏风车子果实提取物具有最强的抗增殖和细胞毒性作用。与风车子叶提取物的强大作用相反，该物种的根提取物在浓度为25微克/毫升时，对所研究的癌细胞系没有细胞毒性作用。其他研究的风车子属和榄仁树属物种在细胞毒性潜力方面差异很大。在本研究中使用的五种榄仁树属植物中，桑贝西榄仁树和绢毛榄仁树的根提取物具有最强的细胞毒性作用。在所研究的24种植物提取物中，有8种对T 24膀胱癌细胞显示出明显的细胞毒性作用（与对照组相比增殖<30%），7种对HeLa细胞有作用，4种对MCF 7细胞有作用。
