Tippett William J, Sergio Lauren E
School of Kinesiology and Health Science, Centre for Vision Research, CIHR Group for Action and Perception, 350 Bethune College, York University, Toronto, ON, Canada.
Brain Res. 2006 Aug 2;1102(1):92-102. doi: 10.1016/j.brainres.2006.04.049. Epub 2006 Jun 23.
When the sensory information guiding a reach movement is dissociated from the required motor output, humans must integrate rule-based information in order to reach accurately. Here, we examine the accuracy of movements requiring a visuomotor transformation in neurologically healthy elderly subjects and patients diagnosed with probable Alzheimer's disease. Participants made sliding finger movements over a clear touch-sensitive screen positioned in three spatial planes to displace a cursor from a central target to one of four peripheral targets viewed on a monitor. These spatial plane conditions were repeated under conditions where the direction of cursor motion was rotated 180 degrees relative to the direction of hand motion. Significant main effects were observed between patient and control groups on reaction time and movement time measures. Also, significant increases in task completion errors were observed in the patient population. Further, performance was affected more by the visual feedback changes relative to the plane location changes. Notably, there were substantial performance deficits observed in the patient population, even those with minimal cognitive deficits. We suggest that the integration of eye and hand information may be impaired in these patients.
当引导伸手动作的感觉信息与所需的运动输出分离时，人类必须整合基于规则的信息才能准确伸手。在此，我们研究了神经功能正常的老年人和被诊断为可能患有阿尔茨海默病的患者中需要视觉运动转换的动作的准确性。参与者在位于三个空间平面的透明触摸感应屏幕上进行滑动手指动作，以使光标从中央目标移动到在监视器上看到的四个外围目标之一。这些空间平面条件在光标运动方向相对于手部运动方向旋转180度的情况下重复进行。在患者组和对照组之间，在反应时间和运动时间测量方面观察到显著的主效应。此外，在患者群体中观察到任务完成错误显著增加。此外，相对于平面位置变化，视觉反馈变化对表现的影响更大。值得注意的是，在患者群体中观察到了明显的表现缺陷，即使是那些认知缺陷最小的患者。我们认为，这些患者的眼手信息整合可能受损。
