Silverman Edwin K
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Proc Am Thorac Soc. 2006 Jul;3(5):405-8. doi: 10.1513/pats.200603-092AW.
Familial aggregation of chronic obstructive pulmonary disease (COPD) has been demonstrated, suggesting that genetic factors likely influence the variable development of chronic airflow obstruction in response to smoking. A variety of approaches have been used to identify novel COPD susceptibility genes, including association studies, linkage analysis, and rare variant analysis. Future directions for COPD research include genomewide association studies and animal model genetic studies.
慢性阻塞性肺疾病(COPD)的家族聚集性已得到证实,这表明遗传因素可能影响对吸烟做出反应的慢性气流阻塞的可变发展。人们已采用多种方法来识别新的COPD易感基因,包括关联研究、连锁分析和罕见变异分析。COPD研究的未来方向包括全基因组关联研究和动物模型遗传学研究。