Ayotte C
INRS-Institut Armand-Frappier, 245, boul. Hymus, Pointe-Claire, Québec H9R 1G6.
Br J Sports Med. 2006 Jul;40 Suppl 1(Suppl 1):i25-9. doi: 10.1136/bjsm.2006.028027.
Nandrolone and other 19-norsteroid potent anabolic steroids have been prohibited in sports for 30 years. The detection of the main urinary metabolite--19-norandrosterone--in amounts greater than 2 ng/ml constitutes an adverse analytical finding. The presence in nutritional sport supplements of steroids not listed on the label has undoubtedly resulted in positive tests, but inadvertent consumption of meat containing residues of hormonal treatment should not realistically cause apprehension. Although highly improbable, athletes should prudently avoid meals composed of pig offal in the hours preceding the test since the consumption of edible parts of a non-castrated pig, containing 19-nortestosterone, has been shown to results in the excretion of 19-norandrosterone in the following hours. Norsteroid metabolites are formed during pregnancy and excreted as minor metabolites of norethisterone, and minute amounts have been identified in some male and female samples when using more sensitive techniques of detection. Whereas exercise does not seem to be a significant factor in 19-norandrosterone excretion, some rare urine samples were found to be a suitable medium for in situ 19-demethylation of urinary metabolites.
诺龙及其他19-去甲甾体强效合成代谢类固醇在体育赛事中已被禁用30年。尿液中主要代谢物——19-去甲雄酮——的检测量若大于2 ng/ml，则构成不利的分析结果。营养性运动补剂中存在未在标签上列出的类固醇无疑导致了检测呈阳性，但无意中食用含有激素处理残留的肉类实际上不应引起担忧。尽管可能性极小，但运动员在检测前数小时应谨慎避免食用猪内脏类食物，因为已证实食用含有19-去甲睾酮的未阉割猪的可食用部分会导致在接下来数小时内排出19-去甲雄酮。在孕期会形成去甲甾体代谢物，并作为炔诺酮的次要代谢物排出，使用更灵敏的检测技术时，在一些男性和女性样本中已鉴定出微量的此类物质。虽然运动似乎并非19-去甲雄酮排泄的重要因素，但发现一些罕见的尿液样本是尿液代谢物原位19-去甲基化的合适介质。
