Hu Peifeng, Bretsky Philip, Crimmins Eileen M, Guralnik Jack M, Reuben David B, Seeman Teresa E
Multicampus Program in Geriatric Medicine and Gerontology, UCLA School of Medicine, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095-1687, USA.
J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):616-20. doi: 10.1093/gerona/61.6.616.
Growing evidence from animal studies suggests an interaction between antioxidants and apolipoprotein E (APOE) alleles on cognitive functioning. We used data from a 7-year cohort study of high-functioning older persons to explore whether the associations between serum beta-carotene level and subsequent decline of cognitive function differed by APOE 4 genotype.
Baseline information on sociodemographic characteristics, serum beta-carotene level, inflammation markers, APOE genotype, and cognitive functioning measured by a 9-item Short Portable Mental Status Questionnaire (SPMSQ) was obtained in 455 survivors. Multivariable logistic regression analyses were used to examine the relation between high serum beta-carotene level and risk of SPMSQ score decline in participants with or without APOE 4 alleles, while adjusting for age, sex, race, baseline SPMSQ score, and other covariates.
Nine (2%) study participants had homozygous and 97 (21%) had heterozygous APOE 4 alleles. Two hundred forty-nine (55%) had decline of SPMSQ scores during the follow-up. The presence of an APOE 4 allele was associated with higher risk and larger magnitude of SPMSQ score decline. The adjusted odds ratio of high beta-carotene level for cognitive decline was 0.11 (95% confidence interval, 0.02-0.57) in participants with at least one APOE 4 allele and 0.89 (95% confidence interval, 0.54-1.47) among those who were APOE 4 negative.
Among high-functioning older persons, antioxidants and beta-carotene in particular may offer protection from cognitive decline in persons with greater genetic susceptibility as evidenced by the presence of the APOE 4 allele.
动物研究的越来越多证据表明抗氧化剂与载脂蛋白E（APOE）等位基因在认知功能方面存在相互作用。我们使用了一项针对高功能老年人的7年队列研究数据，以探讨血清β-胡萝卜素水平与随后认知功能下降之间的关联是否因APOE 4基因型而异。
在455名幸存者中获取了关于社会人口学特征、血清β-胡萝卜素水平、炎症标志物、APOE基因型以及通过9项简短便携式精神状态问卷（SPMSQ）测量的认知功能的基线信息。多变量逻辑回归分析用于检验高血清β-胡萝卜素水平与有或无APOE 4等位基因参与者中SPMSQ评分下降风险之间的关系，同时调整年龄、性别、种族、基线SPMSQ评分和其他协变量。
9名（2%）研究参与者为APOE 4等位基因纯合子，97名（21%）为杂合子。249名（55%）在随访期间SPMSQ评分下降。APOE 4等位基因的存在与SPMSQ评分下降的更高风险和更大幅度相关。在至少有一个APOE 4等位基因的参与者中，高β-胡萝卜素水平导致认知下降的调整优势比为0.11（95%置信区间，0.02 - 0.57），在APOE 4阴性参与者中为0.89（95%置信区间，0.54 - 1.47）。
在高功能老年人中，抗氧化剂尤其是β-胡萝卜素可能为具有更高遗传易感性（如存在APOE 4等位基因所证明）人群的认知下降提供保护。
