Abrego-Guandique Diana Marisol, Bonet Maria Luisa, Caroleo Maria Cristina, Cannataro Roberto, Tucci Paola, Ribot Joan, Cione Erika
Department of Health Sciences, University of Magna Graecia Catanzaro, 88100 Catanzaro, Italy.
Galascreen Laboratories, University of Calabria, 87036 Rende, Italy.
Brain Sci. 2023 Oct 17;13(10):1468. doi: 10.3390/brainsci13101468.
β-carotene is a powerful antioxidant and dietary precursor of vitamin A whose role in maintaining mental health and cognitive performance, either alone or in combination with other dietary compounds, has been a topic of recent research. However, its effectiveness is still unclear. This systematic review, conducted according to the PRISMA guideline and assisted by the MySLR platform, addressed this issue. A total of 16 eligible original research articles were identified. Dietary intake or β-carotene serum levels were associated with improved measures of cognitive function in 7 out of 10 epidemiological studies included. In intervention studies, β-carotene consumption alone did not promote better cognitive function in the short term, but only in a long-term intervention with a mean duration of 18 years. However, all but one intervention study suggested the beneficial effects of β-carotene supplementation at doses ranging from 6 mg to 50 mg per day in combination with a multicomplex such as vitamin E, vitamin C, zinc, or selenium for a period of 16 weeks to 20 years. Despite the current limitations, the available evidence suggests a potential association between β-carotene dietary/supplementary intake and the maintenance of cognitive function. The β-carotene most probably does not act alone but in synergy with other micronutrients.
β-胡萝卜素是一种强大的抗氧化剂，也是维生素A的膳食前体，其在单独或与其他膳食化合物联合维持心理健康和认知表现方面的作用，一直是近期研究的主题。然而，其有效性仍不明确。本系统评价根据PRISMA指南进行，并在MySLR平台的协助下解决了这一问题。共识别出16篇符合条件的原始研究文章。在纳入的10项流行病学研究中，有7项研究表明膳食摄入或β-胡萝卜素血清水平与认知功能改善指标相关。在干预研究中，单独食用β-胡萝卜素在短期内并不能促进更好的认知功能，只有在平均持续时间为18年的长期干预中才会有效果。然而，除一项干预研究外，所有研究均表明，每天补充6毫克至50毫克剂量的β-胡萝卜素，并与维生素E、维生素C、锌或硒等多种复合物联合使用16周至20年，具有有益效果。尽管存在当前的局限性，但现有证据表明β-胡萝卜素的膳食/补充剂摄入与认知功能维持之间可能存在关联。β-胡萝卜素很可能不是单独起作用，而是与其他微量营养素协同作用。
