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[促性腺激素和胎儿垂体对器官培养中18日龄小鼠胎儿睾丸睾酮产生的影响]

[The effect of gonadotropic hormones and the fetal hypophysis on testosterone production by the testis of 18 day mouse fetuses in organ culture].

作者信息

Pointis G, Mahoudeau J A, Courrier R

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 May 26;280(20):2361-4.

PMID:167996
Abstract

The production of testosterone (measured by radioimmuno-assay) by the 18-day-old mouse fetal testis may be stimulated specifically by ovine LH (1 ng, p less than 0.005) and HCG in organ culture. A stimulation by FSH is observed only with high doses (10 mug, p less than 0.0005). Prolactin and ACTH have no effect. Age-matched fetal pituitaries increase significantly the testosterone production in the culture medium (p less than 0.0005).

摘要

通过放射免疫测定法测量,在器官培养中,18日龄小鼠胎儿睾丸产生睾酮的过程可能会受到绵羊促黄体激素(1纳克,p<0.005)和人绒毛膜促性腺激素的特异性刺激。仅在高剂量(10微克,p<0.0005)时观察到促卵泡激素的刺激作用。催乳素和促肾上腺皮质激素没有作用。年龄匹配的胎儿垂体显著增加了培养基中睾酮的产生(p<0.0005)。

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