Hoshino Tomoyuki, Matsumoto Mariko
Hamamatsu ENT Surgicenter, 1696 Tenno-cho, Hamamatsu, Shizuoka 435-0052, Japan.
Eur Arch Otorhinolaryngol. 2006 Sep;263(9):875-8. doi: 10.1007/s00405-006-0076-0. Epub 2006 Jun 24.
Reports on clear identification of fungi in subdermal tissue in chronic fungal external otitis are rare in recent years. Our patient was an immunocompetent adult male with an 8 year history of chronic otitis externa who presented with pustules on the external auditory canal (EAC) and necrosis and perforation of the tympanic membrane. Type I tympanoplasty was performed, but wound healing was delayed and swelling of the EAC occurred. Incision biopsy and staining (Gomori-Grocott and PAS) revealed fungal hyphae within small, calcified, subepidermal masses. A 3 month course of oral itraconazole was effective in healing the lesion. Calcification, a rarely reported finding in otomycosis, may represent a protective reaction against topical use of antifungal drugs.
近年来,关于在慢性真菌性外耳道炎的皮下组织中明确鉴定出真菌的报道很少。我们的患者是一名免疫功能正常的成年男性,有8年慢性外耳道炎病史,表现为外耳道脓疱、鼓膜坏死和穿孔。进行了I型鼓室成形术,但伤口愈合延迟,外耳道出现肿胀。切开活检和染色(Gomori-Grocott和PAS)显示在小的、钙化的表皮下肿块内有真菌菌丝。口服伊曲康唑3个月疗程有效地治愈了病变。钙化在耳霉菌病中是一种很少报道的发现,可能代表了对抗真菌药物局部使用的一种保护反应。