Sánchez-Herrero E
Centro de Biología Molecular, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Development. 1991 Feb;111(2):437-49. doi: 10.1242/dev.111.2.437.
The abdominal-A (abd-A) and Abdominal-B (Abd-B) genes of the bithorax complex (BX-C) specify the identity of most of the Drosophila abdomen. Six different classes of infraabdominal (iab) mutations within the BX-C transform a subset of the parasegments affected by the lack of these two genes. It is thought that these mutations define parasegmental cis-regulatory regions that control the expression of abd-A and Abd-B. By staining embryos mutant for different iab mutations with anti-abd-A and anti-Abd-B antibodies I show here that the expression of Abd-B (and probably also abd-A) exhibit a parasegmental regulation. I have also studied the significance of the chromosomal order of parasegmental iab regulatory sequences, and the possible presence of chromosomal 'boundaries' between them, by looking at the expression of abd-A and Abd-B in embryos carrying the Uab and Mcp mutations. These data are discussed in the light of models of parasegmental-specific regulatory regions within the BX-C.
双胸复合体（BX-C）的腹部-A（abd-A）基因和腹部-B（Abd-B）基因决定了果蝇大部分腹部的特征。BX-C内六种不同类型的腹下（iab）突变会改变受这两个基因缺失影响的副节的一个子集。人们认为这些突变定义了控制abd-A和Abd-B表达的副节顺式调控区域。通过用抗abd-A和抗Abd-B抗体对不同iab突变的胚胎进行染色，我在此表明Abd-B（可能还有abd-A）的表达呈现出副节调控。我还通过观察携带Uab和Mcp突变的胚胎中abd-A和Abd-B的表达，研究了副节iab调控序列的染色体顺序的重要性，以及它们之间可能存在的染色体“边界”。根据BX-C内副节特异性调控区域的模型对这些数据进行了讨论。
