Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia.
Int J Mol Sci. 2023 Feb 2;24(3):2855. doi: 10.3390/ijms24032855.
In higher eukaryotes, the regulation of developmental gene expression is determined by enhancers, which are often located at a large distance from the promoters they regulate. Therefore, the architecture of chromosomes and the mechanisms that determine the functional interaction between enhancers and promoters are of decisive importance in the development of organisms. Mammals and the model animal have homologous key architectural proteins and similar mechanisms in the organization of chromosome architecture. This review describes the current progress in understanding the mechanisms of the formation and regulation of long-range interactions between enhancers and promoters at three well-studied key regulatory loci in
在高等真核生物中，发育基因表达的调控是由增强子决定的，而增强子通常位于它们所调控的启动子的很大距离处。因此，染色体的结构和决定增强子与启动子之间功能相互作用的机制在生物体的发育中具有决定性的重要性。哺乳动物和模型动物在染色体结构的组织中具有同源的关键结构蛋白和相似的机制。这篇综述描述了在三个研究得很好的关键调控基因座中，理解增强子和启动子之间长程相互作用的形成和调控机制的当前进展。
