Bloor Roger N, Spanĕl Patrick, Smith David
Academic Psychiatry Unit, Keele University Medical School, Academic Suite, Harplands Hospital, UK.
Addict Biol. 2006 Jun;11(2):163-9. doi: 10.1111/j.1369-1600.2006.00015.x.
Selected ion flow tube mass spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse). Carbon disulphide is a product of the metabolism of disulfiram and is excreted mainly through the lungs. Acetone is a product of normal metabolism and appears in the breath of all individuals. These breath analyses were performed in single exhalations and the results were available in real time. The levels of breath acetone and carbon disulphide were compared with levels obtained from a control subject who had not ingested disulfiram. Breath carbon disulphide was seen to increase from 15 p.p.b. to 618 p.p.b. over a 28-hour period, in the single individual tested, following ingestion of disulfiram, while acetone levels increased from 300 p.p.b. (normal) to over 4000 p.p.b. (greatly elevated). No such increases were seen in the breath of the control subject over the same period. An obvious positive correlation between breath carbon disulphide and acetone concentrations following disulfiram ingestion is seen and discussed.
采用选择离子流管质谱法（SIFT-MS），在单次服用双硫仑（戒酒硫）后，同时测量呼出气体中二硫化碳和丙酮的浓度。二硫化碳是双硫仑代谢的产物，主要通过肺部排出。丙酮是正常代谢的产物，存在于所有人的呼出气体中。这些呼出气体分析在单次呼气时进行，结果可实时获取。将呼出气体中丙酮和二硫化碳的水平与未服用双硫仑的对照受试者的水平进行比较。在测试的单个受试者中，服用双硫仑后，呼出气体中二硫化碳在28小时内从15 ppb增加到618 ppb，而丙酮水平从300 ppb（正常）增加到超过4000 ppb（大幅升高）。在同一时期，对照受试者的呼出气体中未出现此类增加。观察并讨论了服用双硫仑后呼出气体中二硫化碳与丙酮浓度之间明显的正相关关系。
