Lashbrook Daniel J, James Roger W, Phillips Andrea J, Holbrook Anthony G, Agombar Andrew C
Department of General Surgery, Royal United Hospital, Combe Park, Bath, UK.
BMC Surg. 2006 Jun 26;6:9. doi: 10.1186/1471-2482-6-9.
Peliosis is a rare condition characterised by multiple cyst-like, blood-filled cavities within the parenchyma of solid organs. Most commonly affecting the liver, isolated splenic peliosis is an even more unique phenomenon. Patients with the condition are often asymptomatic. However, this potentially lethal condition can present with spontaneous organ rupture. We present two such cases, discuss their management and review what is currently known in the existing literature.
A previously well twenty-six year old woman presented with abdominal pain following a trivial episode of coughing. A diagnosis of spontaneous splenic rupture was made following clinical and radiological examination. She underwent emergency splenectomy and made a full, uneventful recovery. Histopathological examination confirmed splenic peliosis. The second case describes an eighty six year old lady who sustained a trivial fall and developed pain in her left side. A CT confirmed splenic rupture. She became haemodynamically unstable during her admission and underwent emergency splenectomy. Histopathological examination revealed splenic peliosis. She went on to make an uneventful recovery.
Splenic peliosis is very rare. It has a number of associations including immunosuppression, drug therapy and infection. Although patients are often asymptomatic, life-threatening spontaneous organ rupture may occur. If the diagnosis of peliosis is confirmed, additional investigations should be considered to detect its presence in other organs. Furthermore, the presence of the condition may be relevant if further medical or surgical intervention is planned.
紫癜是一种罕见病症，其特征为实性器官实质内出现多个囊肿样、充满血液的腔隙。最常累及肝脏，孤立性脾紫癜更是一种独特现象。患有该病的患者通常无症状。然而，这种潜在致命病症可能会出现自发性器官破裂。我们报告两例此类病例，讨论其治疗方法并回顾现有文献中的相关已知内容。
一名26岁既往健康的女性在轻微咳嗽后出现腹痛。经临床和影像学检查后诊断为自发性脾破裂。她接受了急诊脾切除术，术后完全康复，过程顺利。组织病理学检查证实为脾紫癜。第二例是一位86岁的女性，她轻微跌倒后左侧出现疼痛。CT检查证实脾破裂。她在住院期间血流动力学不稳定，接受了急诊脾切除术。组织病理学检查显示为脾紫癜。她随后顺利康复。
脾紫癜非常罕见。它与多种因素有关，包括免疫抑制、药物治疗和感染。尽管患者通常无症状，但可能会发生危及生命的自发性器官破裂。如果紫癜诊断得到证实，应考虑进行进一步检查以检测其他器官是否存在该病。此外，如果计划进行进一步的医疗或手术干预，该病的存在可能具有相关性。
